Natural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic Infection.
Identifieur interne : 000C60 ( Main/Exploration ); précédent : 000C59; suivant : 000C61Natural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic Infection.
Auteurs : Erica S. Lovelace [États-Unis] ; Stephen J. Polyak [États-Unis]Source :
- Viruses [ 1999-4915 ] ; 2015.
Descripteurs français
- KwdFr :
- Curcumine (pharmacologie), Facteurs immunologiques (pharmacologie), Humains (MeSH), Hépatite C (anatomopathologie), Immunité cellulaire (effets des médicaments et des substances chimiques), Infections à VIH (anatomopathologie), Inflammation (anatomopathologie), Maladie chronique (MeSH), Produits biologiques (pharmacologie), Resvératrol (MeSH), Silymarine (pharmacologie), Stilbènes (pharmacologie).
- MESH :
- anatomopathologie : Hépatite C, Infections à VIH, Inflammation.
- effets des médicaments et des substances chimiques : Immunité cellulaire.
- pharmacologie : Curcumine, Facteurs immunologiques, Produits biologiques, Silymarine, Stilbènes.
- Humains, Maladie chronique, Resvératrol.
English descriptors
- KwdEn :
- Biological Products (pharmacology), Chronic Disease (MeSH), Curcumin (pharmacology), HIV Infections (pathology), Hepatitis C (pathology), Humans (MeSH), Immunity, Cellular (drug effects), Immunologic Factors (pharmacology), Inflammation (pathology), Resveratrol (MeSH), Silymarin (pharmacology), Stilbenes (pharmacology).
- MESH :
- chemical , pharmacology : Biological Products, Curcumin, Immunologic Factors, Silymarin, Stilbenes.
- drug effects : Immunity, Cellular.
- pathology : HIV Infections, Hepatitis C, Inflammation.
- Chronic Disease, Humans, Resveratrol.
Abstract
Chronic viral infections like those caused by hepatitis C virus (HCV) and human immunodeficiency virus (HIV) cause disease that establishes an ongoing state of chronic inflammation. While there have been tremendous improvements towards curing HCV with directly acting antiviral agents (DAA) and keeping HIV viral loads below detection with antiretroviral therapy (ART), there is still a need to control inflammation in these diseases. Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-κB) and immune function. Natural products represent a vast toolkit to dissect and define how cellular metabolism controls cellular immune and inflammatory function.
DOI: 10.3390/v7122933
PubMed: 26633463
PubMed Central: PMC4690857
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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While there have been tremendous improvements towards curing HCV with directly acting antiviral agents (DAA) and keeping HIV viral loads below detection with antiretroviral therapy (ART), there is still a need to control inflammation in these diseases. Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-κB) and immune function. Natural products represent a vast toolkit to dissect and define how cellular metabolism controls cellular immune and inflammatory function. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26633463</PMID><DateCompleted><Year>2016</Year><Month>09</Month><Day>29</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1999-4915</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>12</Issue><PubDate><Year>2015</Year><Month>Nov</Month><Day>30</Day></PubDate></JournalIssue><Title>Viruses</Title><ISOAbbreviation>Viruses</ISOAbbreviation></Journal><ArticleTitle>Natural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic Infection.</ArticleTitle><Pagination><MedlinePgn>6218-32</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3390/v7122933</ELocationID><Abstract><AbstractText>Chronic viral infections like those caused by hepatitis C virus (HCV) and human immunodeficiency virus (HIV) cause disease that establishes an ongoing state of chronic inflammation. While there have been tremendous improvements towards curing HCV with directly acting antiviral agents (DAA) and keeping HIV viral loads below detection with antiretroviral therapy (ART), there is still a need to control inflammation in these diseases. Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-κB) and immune function. Natural products represent a vast toolkit to dissect and define how cellular metabolism controls cellular immune and inflammatory function. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lovelace</LastName><ForeName>Erica S</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA. elove@uw.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Polyak</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA. polyak@uw.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology, University of Washington, Seattle, WA 98195, USA. polyak@uw.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Global Health, University of Washington, Seattle, WA 98195, USA. 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name="Washington (État)"><name sortKey="Lovelace, Erica S" sort="Lovelace, Erica S" uniqKey="Lovelace E" first="Erica S" last="Lovelace">Erica S. Lovelace</name></region><name sortKey="Polyak, Stephen J" sort="Polyak, Stephen J" uniqKey="Polyak S" first="Stephen J" last="Polyak">Stephen J. Polyak</name><name sortKey="Polyak, Stephen J" sort="Polyak, Stephen J" uniqKey="Polyak S" first="Stephen J" last="Polyak">Stephen J. Polyak</name><name sortKey="Polyak, Stephen J" sort="Polyak, Stephen J" uniqKey="Polyak S" first="Stephen J" last="Polyak">Stephen J. Polyak</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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